Title |
Hypoxylon pulicicidum sp. nov. (Ascomycota, Xylariales), a Pantropical Insecticide-Producing Endophyte
|
---|---|
Published in |
PLOS ONE, October 2012
|
DOI | 10.1371/journal.pone.0046687 |
Pubmed ID | |
Authors |
Gerald F. Bills, Victor González-Menéndez, Jesús Martín, Gonzalo Platas, Jacques Fournier, Derek Peršoh, Marc Stadler |
Abstract |
Nodulisporic acids (NAs) are indole diterpene fungal metabolites exhibiting potent systemic efficacy against blood-feeding arthropods, e.g., bedbugs, fleas and ticks, via binding to arthropod specific glutamate-gated chloride channels. Intensive medicinal chemistry efforts employing a nodulisporic acid A template have led to the development of N-tert-butyl nodulisporamide as a product candidate for a once monthly treatment of fleas and ticks on companion animals. The source of the NAs is a monophyletic lineage of asexual endophytic fungal strains that is widely distributed in the tropics, tentatively identified as a Nodulisporium species and hypothesized to be the asexual state of a Hypoxylon species. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Brazil | 1 | <1% |
Germany | 1 | <1% |
Argentina | 1 | <1% |
India | 1 | <1% |
Unknown | 106 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 20 | 18% |
Student > Master | 19 | 17% |
Student > Ph. D. Student | 18 | 16% |
Researcher | 16 | 14% |
Student > Doctoral Student | 4 | 4% |
Other | 16 | 14% |
Unknown | 19 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 45 | 40% |
Biochemistry, Genetics and Molecular Biology | 14 | 13% |
Chemistry | 12 | 11% |
Environmental Science | 7 | 6% |
Engineering | 3 | 3% |
Other | 8 | 7% |
Unknown | 23 | 21% |