Title |
The Polyoma Virus Large T Binding Protein p150 Is a Transcriptional Repressor of c-MYC
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Published in |
PLOS ONE, September 2012
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DOI | 10.1371/journal.pone.0046486 |
Pubmed ID | |
Authors |
Chang Kyoo Sung, Hyungshin Yim, Hongcang Gu, Dawei Li, Erik Andrews, Sekhar Duraisamy, Cheng Li, Ronny Drapkin, Thomas Benjamin |
Abstract |
p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The Cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 50% |
Equatorial Guinea | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 32% |
Student > Ph. D. Student | 5 | 20% |
Other | 3 | 12% |
Researcher | 2 | 8% |
Student > Master | 2 | 8% |
Other | 3 | 12% |
Unknown | 2 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 36% |
Agricultural and Biological Sciences | 8 | 32% |
Medicine and Dentistry | 3 | 12% |
Computer Science | 1 | 4% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 3 | 12% |