| Title |
Plasma Uric Acid Levels Correlate with Inflammation and Disease Severity in Malian Children with Plasmodium falciparum Malaria
|
|---|---|
| Published in |
PLOS ONE, October 2012
|
| DOI | 10.1371/journal.pone.0046424 |
| Pubmed ID | |
| Authors |
Tatiana M. Lopera-Mesa, Neida K. Mita-Mendoza, Diana L. van de Hoef, Saibou Doumbia, Drissa Konaté, Mory Doumbouya, Wenjuan Gu, Karim Traoré, Seidina A. S. Diakité, Alan T. Remaley, Jennifer M. Anderson, Ana Rodriguez, Michael P. Fay, Carole A. Long, Mahamadou Diakité, Rick M. Fairhurst |
| Abstract |
Plasmodium falciparum elicits host inflammatory responses that cause the symptoms and severe manifestations of malaria. One proposed mechanism involves formation of immunostimulatory uric acid (UA) precipitates, which are released from sequestered schizonts into microvessels. Another involves hypoxanthine and xanthine, which accumulate in parasitized red blood cells (RBCs) and may be converted by plasma xanthine oxidase to UA at schizont rupture. These two forms of 'parasite-derived' UA stimulate immune cells to produce inflammatory cytokines in vitro. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Unknown | 55 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 10 | 18% |
| Student > Master | 8 | 14% |
| Student > Postgraduate | 5 | 9% |
| Student > Doctoral Student | 4 | 7% |
| Researcher | 4 | 7% |
| Other | 10 | 18% |
| Unknown | 15 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 21% |
| Agricultural and Biological Sciences | 10 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 5% |
| Immunology and Microbiology | 3 | 5% |
| Other | 9 | 16% |
| Unknown | 14 | 25% |