| Title |
Biofilm Modifies Expression of Ribonucleotide Reductase Genes in Escherichia coli
|
|---|---|
| Published in |
PLOS ONE, September 2012
|
| DOI | 10.1371/journal.pone.0046350 |
| Pubmed ID | |
| Authors |
Maria del Mar Cendra, Antonio Juárez, Eduard Torrents |
| Abstract |
Ribonucleotide reductase (RNR) is an essential enzyme for all living organisms since is the responsible for the last step in the synthesis of the four deoxyribonucleotides (dNTPs) necessary for DNA replication and repair. In this work, we have investigated the expression of the three-RNR classes (Ia, Ib and III) during Escherichia coli biofilm formation. We show the temporal and spatial importance of class Ib and III RNRs during this process in two different E. coli wild-type strains, the commensal MG1655 and the enteropathogenic and virulent E2348/69, the prototype for the enteropathogenic E. coli (EPEC). We have established that class Ib RNR, so far considered cryptic, play and important role during biofilm formation. The implication of this RNR class under the specific growth conditions of biofilm formation is discussed. |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 2% |
| Unknown | 41 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 21% |
| Student > Bachelor | 7 | 17% |
| Researcher | 7 | 17% |
| Student > Master | 6 | 14% |
| Student > Postgraduate | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 8 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 31% |
| Biochemistry, Genetics and Molecular Biology | 7 | 17% |
| Immunology and Microbiology | 5 | 12% |
| Chemistry | 4 | 10% |
| Medicine and Dentistry | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 8 | 19% |