Title |
Acute Plasma Biomarkers of T Cell Activation Set-Point Levels and of Disease Progression in HIV-1 Infection
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Published in |
PLOS ONE, October 2012
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DOI | 10.1371/journal.pone.0046143 |
Pubmed ID | |
Authors |
Anne-Sophie Liovat, Marie-Anne Rey-Cuillé, Camille Lécuroux, Béatrice Jacquelin, Isabelle Girault, Gaël Petitjean, Yasmine Zitoun, Alain Venet, Françoise Barré-Sinoussi, Pierre Lebon, Laurence Meyer, Martine Sinet, Michaela Müller-Trutwin |
Abstract |
T cell activation levels, viral load and CD4(+) T cell counts at early stages of HIV-1 infection are predictive of the rate of progression towards AIDS. We evaluated whether the inflammatory profile during primary HIV-1 infection is predictive of the virological and immunological set-points and of disease progression. We quantified 28 plasma proteins during acute and post-acute HIV-1 infection in individuals with known disease progression profiles. Forty-six untreated patients, enrolled during primary HIV-1 infection, were categorized into rapid progressors, progressors and slow progressors according to their spontaneous progression profile over 42 months of follow-up. Already during primary infection, rapid progressors showed a higher number of increased plasma proteins than progressors or slow progressors. The plasma levels of TGF-β1 and IL-18 in primary HIV-1 infection were both positively associated with T cell activation level at set-point (6 months after acute infection) and together able to predict 74% of the T cell activation variation at set-point. Plasma IP-10 was positively and negatively associated with, respectively, T cell activation and CD4(+) T cell counts at set-point and capable to predict 30% of the CD4(+) T cell count variation at set-point. Moreover, plasma IP-10 levels during primary infection were predictive of rapid progression. In primary infection, IP-10 was an even better predictor of rapid disease progression than viremia or CD4(+) T cell levels at this time point. The superior predictive capacity of IP-10 was confirmed in an independent group of 88 HIV-1 infected individuals. Altogether, this study shows that the inflammatory profile in primary HIV-1 infection is associated with T cell activation levels and CD4(+) T cell counts at set-point. Plasma IP-10 levels were of strong predictive value for rapid disease progression. The data suggest IP-10 being an earlier marker of disease progression than CD4(+) T cell counts or viremia levels. |
X Demographics
Geographical breakdown
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Spain | 1 | 1% |
Puerto Rico | 1 | 1% |
Argentina | 1 | 1% |
Unknown | 92 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 23 | 24% |
Student > Ph. D. Student | 16 | 17% |
Student > Master | 13 | 14% |
Student > Postgraduate | 8 | 8% |
Student > Doctoral Student | 7 | 7% |
Other | 19 | 20% |
Unknown | 9 | 9% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 28 | 29% |
Medicine and Dentistry | 21 | 22% |
Agricultural and Biological Sciences | 21 | 22% |
Biochemistry, Genetics and Molecular Biology | 6 | 6% |
Nursing and Health Professions | 2 | 2% |
Other | 7 | 7% |
Unknown | 10 | 11% |