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A Candidate-Gene Association Study for Berry Colour and Anthocyanin Content in Vitis vinifera L.

Overview of attention for article published in PLOS ONE, September 2012
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Title
A Candidate-Gene Association Study for Berry Colour and Anthocyanin Content in Vitis vinifera L.
Published in
PLOS ONE, September 2012
DOI 10.1371/journal.pone.0046021
Pubmed ID
Authors

Silvana Cardoso, Winston Lau, José Eiras Dias, Pedro Fevereiro, Nikolas Maniatis

Abstract

Anthocyanin content is a trait of major interest in Vitis vinifera L. These compounds affect grape and wine quality, and have beneficial effects on human health. A candidate-gene approach was used to identify genetic variants associated with anthocyanin content in grape berries. A total of 445 polymorphisms were identified in 5 genes encoding transcription factors and 10 genes involved in either the biosynthetic pathway or transport of anthocyanins. A total of 124 SNPs were selected to examine association with a wide range of phenotypes based on RP-HPLC analysis and visual characterization. The phenotypes were total skin anthocyanin (TSA) concentration but also specific types of anthocyanins and relative abundance. The visual assessment was based on OIV (Organisation Internationale de la Vigne et du Vin) descriptors for berry and skin colour. The genes encoding the transcription factors MYB11, MYBCC and MYC(B) were significantly associated with TSA concentration. UFGT and MRP were associated with several different types of anthocyanins. Skin and pulp colour were associated with nine genes (MYB11, MYBCC, MYC(B), UFGT, MRP, DFR, LDOX, CHI and GST). Pulp colour was associated with a similar group of 11 genes (MYB11, MYBCC, MYC(B), MYC(A), UFGT, MRP, GST, DFR, LDOX, CHI and CHS(A)). Statistical interactions were observed between SNPs within the transcription factors MYB11, MYBCC and MYC(B). SNPs within LDOX interacted with MYB11 and MYC(B), while SNPs within CHI interacted with MYB11 only. Together, these findings suggest the involvement of these genes in anthocyanin content and on the regulation of anthocyanin biosynthesis. This work forms a benchmark for replication and functional studies.

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Mendeley readers

The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Portugal 1 1%
Germany 1 1%
Netherlands 1 1%
Chile 1 1%
Uruguay 1 1%
Spain 1 1%
Unknown 73 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 24 30%
Researcher 13 16%
Student > Master 9 11%
Student > Bachelor 8 10%
Student > Doctoral Student 4 5%
Other 9 11%
Unknown 12 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 50 63%
Biochemistry, Genetics and Molecular Biology 10 13%
Medicine and Dentistry 3 4%
Social Sciences 2 3%
Arts and Humanities 1 1%
Other 2 3%
Unknown 11 14%