| Title |
Irrelevance of Microsatellite Instability in the Epidemiology of Sporadic Pancreatic Ductal Adenocarcinoma
|
|---|---|
| Published in |
PLOS ONE, September 2012
|
| DOI | 10.1371/journal.pone.0046002 |
| Pubmed ID | |
| Authors |
Luigi Laghi, Stefania Beghelli, Antonino Spinelli, Paolo Bianchi, Gianluca Basso, Giuseppe Di Caro, Anna Brecht, Giuseppe Celesti, Giona Turri, Samantha Bersani, Guido Schumacher, Christoph Röcken, Ilona Gräntzdörffer, Massimo Roncalli, Alessandro Zerbi, Peter Neuhaus, Claudio Bassi, Marco Montorsi, Aldo Scarpa, Alberto Malesci |
| Abstract |
Pancreatic cancer risk is increased in Lynch syndrome (LS) patients with mismatch repair gene defects predisposing to colonic and extracolonic cancers with microsatellite instability (MSI). However, the frequency of MSI pancreatic cancers has never been ascertained in consecutive, unselected clinical series, and their contribution to the sporadic and inherited burden of pancreatic cancer remains to be established. Aims of the study were to determine the prevalence of MSI in surgically resected pancreatic cancers in a multicentric, retrospective study, and to assess the occurrence of pancreatic cancer in LS. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 46 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 25% |
| Student > Ph. D. Student | 8 | 17% |
| Student > Bachelor | 5 | 10% |
| Student > Master | 4 | 8% |
| Other | 3 | 6% |
| Other | 5 | 10% |
| Unknown | 11 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 17 | 35% |
| Biochemistry, Genetics and Molecular Biology | 10 | 21% |
| Agricultural and Biological Sciences | 3 | 6% |
| Psychology | 2 | 4% |
| Arts and Humanities | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 14 | 29% |