Title |
Microscopic Particles in Two Fractions of Fresh Cerebrospinal Fluid in Twins with Schizophrenia or Bipolar Disorder and in Healthy Controls
|
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Published in |
PLOS ONE, September 2012
|
DOI | 10.1371/journal.pone.0045994 |
Pubmed ID | |
Authors |
Viktoria Johansson, Rolf Nybom, Lennart Wetterberg, Christina M. Hultman, Tyrone D. Cannon, Anette G. M. Johansson, Carl Johan Ekman, Mikael Landén |
Abstract |
Using scanning electron microscopy, microscopic structures have been identified in fresh cerebrospinal fluid (CSF) in patients with schizophrenia and bipolar disorder, but only rarely in control subjects. However, it has not been determined whether these microscopic particles represent state or trait markers, i.e. if their presence is related to clinical manifestations of the disease or if they also can be found in as yet asymptomatic individuals with a genetic liability. This question can be addressed by studying twins discordant or concordant for schizophrenia or bipolar disorder. |
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