| Title |
Chronic Cladribine Administration Increases Amyloid Beta Peptide Generation and Plaque Burden in Mice
|
|---|---|
| Published in |
PLOS ONE, October 2012
|
| DOI | 10.1371/journal.pone.0045841 |
| Pubmed ID | |
| Authors |
Crystal D. Hayes, Debleena Dey, Juan Pablo Palavicini, Hongjie Wang, Wataru Araki, Madepalli K. Lakshmana |
| Abstract |
The clinical uses of 2-chloro-2'-deoxyadenosine (2-CDA) or cladribine which was initially prescribed to patients with hematological and lymphoid cancers is now extended to treat patients with multiple sclerosis (MS). Previous data has shown that 2-CDA has high affinity to the brain and readily passes through the blood brain barrier reaching CSF concentrations 25% of that found in plasma. However, whether long-term administration of 2-CDA can lead to any adverse effects in patients or animal models is not yet clearly known. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 39 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 3% |
| Canada | 1 | 3% |
| Unknown | 37 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 21% |
| Student > Ph. D. Student | 6 | 15% |
| Professor > Associate Professor | 4 | 10% |
| Student > Master | 4 | 10% |
| Student > Bachelor | 3 | 8% |
| Other | 8 | 21% |
| Unknown | 6 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 26% |
| Medicine and Dentistry | 9 | 23% |
| Agricultural and Biological Sciences | 3 | 8% |
| Psychology | 3 | 8% |
| Biochemistry, Genetics and Molecular Biology | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 10 | 26% |