| Title |
Identification of Prostate-Specific G-Protein Coupled Receptor as a Tumor Antigen Recognized by CD8+ T Cells for Cancer Immunotherapy
|
|---|---|
| Published in |
PLOS ONE, September 2012
|
| DOI | 10.1371/journal.pone.0045756 |
| Pubmed ID | |
| Authors |
Satoko Matsueda, Mingjun Wang, Jinsheng Weng, Ying Li, Bingnan Yin, Jia Zou, Qingtian Li, Wei Zhao, Weiyi Peng, Xavier Legras, Christopher Loo, Rong-Fu Wang, Helen Y. Wang |
| Abstract |
Prostate cancer is the most common cancer among elderly men in the US, and immunotherapy has been shown to be a promising strategy to treat patients with metastatic castration-resistant prostate cancer. Efforts to identify novel prostate specific tumor antigens will facilitate the development of effective cancer vaccines against prostate cancer. Prostate-specific G-protein coupled receptor (PSGR) is a novel antigen that has been shown to be specifically over-expressed in human prostate cancer tissues. In this study, we describe the identification of PSGR-derived peptide epitopes recognized by CD8(+) T cells in an HLA-A2 dependent manner. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 25% |
| Student > Master | 7 | 19% |
| Researcher | 5 | 14% |
| Student > Bachelor | 4 | 11% |
| Other | 3 | 8% |
| Other | 5 | 14% |
| Unknown | 3 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 22% |
| Biochemistry, Genetics and Molecular Biology | 8 | 22% |
| Medicine and Dentistry | 5 | 14% |
| Neuroscience | 2 | 6% |
| Immunology and Microbiology | 2 | 6% |
| Other | 4 | 11% |
| Unknown | 7 | 19% |