| Title |
Characterization of In Vivo Dlg1 Deletion on T Cell Development and Function
|
|---|---|
| Published in |
PLOS ONE, September 2012
|
| DOI | 10.1371/journal.pone.0045276 |
| Pubmed ID | |
| Authors |
Lisa A. Humphries, Meredith H. Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O. Humbert, Oscar Silva, June L. Round, Kogo Takamiya, Richard L. Huganir, Janis K. Burkhardt, Sarah M. Russell, M. Carrie Miceli |
| Abstract |
The polarized reorganization of the T cell membrane and intracellular signaling molecules in response to T cell receptor (TCR) engagement has been implicated in the modulation of T cell development and effector responses. In siRNA-based studies Dlg1, a MAGUK scaffold protein and member of the Scribble polarity complex, has been shown to play a role in T cell polarity and TCR signal specificity, however the role of Dlg1 in T cell development and function in vivo remains unclear. |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 5% |
| Germany | 1 | 5% |
| Switzerland | 1 | 5% |
| Unknown | 17 | 85% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 15% |
| Student > Ph. D. Student | 3 | 15% |
| Other | 2 | 10% |
| Professor | 2 | 10% |
| Librarian | 2 | 10% |
| Other | 4 | 20% |
| Unknown | 4 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 30% |
| Immunology and Microbiology | 4 | 20% |
| Biochemistry, Genetics and Molecular Biology | 2 | 10% |
| Medicine and Dentistry | 2 | 10% |
| Business, Management and Accounting | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 20% |