Title |
The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice
|
---|---|
Published in |
PLOS ONE, September 2012
|
DOI | 10.1371/journal.pone.0045156 |
Pubmed ID | |
Authors |
Adam L. Hartman, Polan Santos, Alison Dolce, J. Marie Hardwick |
Abstract |
The mammalian target of rapamycin (mTOR) pathway integrates signals from different nutrient sources, including amino acids and glucose. Compounds that inhibit mTOR kinase activity such as rapamycin and everolimus can suppress seizures in some chronic animal models and in patients with tuberous sclerosis. However, it is not known whether mTOR inhibitors exert acute anticonvulsant effects in addition to their longer term antiepileptogenic effects. To gain insights into how rapamycin suppresses seizures, we investigated the anticonvulsant activity of rapamycin using acute seizure tests in mice. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
Country | Count | As % |
---|---|---|
Chile | 1 | 33% |
Egypt | 1 | 33% |
Unknown | 1 | 33% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 33% |
Members of the public | 1 | 33% |
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 2 | 3% |
Spain | 1 | 1% |
United States | 1 | 1% |
Unknown | 74 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 16 | 21% |
Researcher | 14 | 18% |
Student > Bachelor | 12 | 15% |
Student > Master | 12 | 15% |
Professor > Associate Professor | 4 | 5% |
Other | 11 | 14% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 16 | 21% |
Neuroscience | 15 | 19% |
Agricultural and Biological Sciences | 12 | 15% |
Biochemistry, Genetics and Molecular Biology | 8 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
Other | 13 | 17% |
Unknown | 9 | 12% |