| Title |
Dynamin 1 Regulates Amyloid Generation through Modulation of BACE-1
|
|---|---|
| Published in |
PLOS ONE, September 2012
|
| DOI | 10.1371/journal.pone.0045033 |
| Pubmed ID | |
| Authors |
Li Zhu, Meng Su, Louise Lucast, Lijuan Liu, William J. Netzer, Samuel E. Gandy, Dongming Cai |
| Abstract |
Several lines of investigation support the notion that endocytosis is crucial for Alzheimer's disease (AD) pathogenesis. Substantial evidence have already been reported regarding the mechanisms underlying amyloid precursor protein (APP) traffic, but the regulation of beta-site APP-Cleaving Enzyme 1 (BACE-1) distribution among endosomes, TGN and plasma membrane remains unclear. Dynamin, an important adaptor protein that controls sorting of many molecules, has recently been associated with AD but its functions remain controversial. Here we studied possible roles for dynamin 1 (dyn1) in Aβ biogenesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 55 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 55 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 22% |
| Student > Ph. D. Student | 9 | 16% |
| Student > Master | 6 | 11% |
| Student > Bachelor | 5 | 9% |
| Professor > Associate Professor | 4 | 7% |
| Other | 10 | 18% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 24% |
| Agricultural and Biological Sciences | 13 | 24% |
| Neuroscience | 9 | 16% |
| Medicine and Dentistry | 4 | 7% |
| Immunology and Microbiology | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 13 | 24% |