Title |
Transposable Elements in TDP-43-Mediated Neurodegenerative Disorders
|
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Published in |
PLOS ONE, September 2012
|
DOI | 10.1371/journal.pone.0044099 |
Pubmed ID | |
Authors |
Wanhe Li, Ying Jin, Lisa Prazak, Molly Hammell, Josh Dubnau |
Abstract |
Elevated expression of specific transposable elements (TEs) has been observed in several neurodegenerative disorders. TEs also can be active during normal neurogenesis. By mining a series of deep sequencing datasets of protein-RNA interactions and of gene expression profiles, we uncovered extensive binding of TE transcripts to TDP-43, an RNA-binding protein central to amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). Second, we find that association between TDP-43 and many of its TE targets is reduced in FTLD patients. Third, we discovered that a large fraction of the TEs to which TDP-43 binds become de-repressed in mouse TDP-43 disease models. We propose the hypothesis that TE mis-regulation contributes to TDP-43 related neurodegenerative diseases. |
X Demographics
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United Kingdom | 2 | 22% |
United States | 2 | 22% |
France | 2 | 22% |
Netherlands | 1 | 11% |
Egypt | 1 | 11% |
Unknown | 1 | 11% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 6 | 67% |
Scientists | 2 | 22% |
Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
Geographical breakdown
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Canada | 2 | <1% |
Italy | 1 | <1% |
United Kingdom | 1 | <1% |
Brazil | 1 | <1% |
Belgium | 1 | <1% |
United States | 1 | <1% |
Unknown | 207 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 48 | 22% |
Student > Bachelor | 32 | 15% |
Researcher | 30 | 14% |
Student > Master | 17 | 8% |
Student > Doctoral Student | 15 | 7% |
Other | 27 | 13% |
Unknown | 45 | 21% |
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---|---|---|
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Biochemistry, Genetics and Molecular Biology | 54 | 25% |
Neuroscience | 23 | 11% |
Medicine and Dentistry | 14 | 7% |
Social Sciences | 2 | <1% |
Other | 7 | 3% |
Unknown | 48 | 22% |