| Title |
Blunted IL17/IL22 and Pro-Inflammatory Cytokine Responses in the Genital Tract and Blood of HIV-Exposed, Seronegative Female Sex Workers in Kenya
|
|---|---|
| Published in |
PLOS ONE, August 2012
|
| DOI | 10.1371/journal.pone.0043670 |
| Pubmed ID | |
| Authors |
Duncan Chege, Yijie Chai, Sanja Huibner, Taylor Kain, Charles Wachihi, Makubo Kimani, Samson Barasa, Lyle R. McKinnon, Festus K. Muriuki, Anthony Kariri, Walter Jaoko, Omu Anzala, Joshua Kimani, T. Blake Ball, Francis A. Plummer, Rupert Kaul |
| Abstract |
Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced systemic immune activation has been described in HESN individuals. Conversely, pro-inflammatory T cell subsets, particularly CD4+ T cells producing the cytokine IL17 (Th17 cells), may represent a highly susceptible target for HIV infection after sexual exposure. Therefore, we characterized the cellular pro-inflammatory and IL17/IL22 cytokine immune milieu in the genital mucosa and blood of HESN female sex workers (FSWs). |
Mendeley readers
The data shown below were compiled from readership statistics for 78 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| United States | 1 | 1% |
| Kenya | 1 | 1% |
| South Africa | 1 | 1% |
| Unknown | 74 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 18% |
| Student > Ph. D. Student | 13 | 17% |
| Professor > Associate Professor | 11 | 14% |
| Student > Master | 10 | 13% |
| Student > Postgraduate | 6 | 8% |
| Other | 16 | 21% |
| Unknown | 8 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 24 | 31% |
| Agricultural and Biological Sciences | 19 | 24% |
| Immunology and Microbiology | 10 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 6% |
| Social Sciences | 3 | 4% |
| Other | 9 | 12% |
| Unknown | 8 | 10% |