| Title |
Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation
|
|---|---|
| Published in |
PLOS ONE, August 2012
|
| DOI | 10.1371/journal.pone.0043580 |
| Pubmed ID | |
| Authors |
Spencer B. Hermanson, Coby B. Carlson, Steven M. Riddle, Jing Zhao, Kurt W. Vogel, R. Jeremy Nichols, Kun Bi |
| Abstract |
Mutations in the leucine-rich repeat kinase-2 (LRRK2) have been linked to Parkinson's disease. Recent studies show that inhibition of LRRK2 kinase activity decreased the level of phosphorylation at its own Ser910 and Ser935, indicating that these sites are prime targets for cellular readouts of LRRK2 inhibition. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 69 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 22 | 31% |
| Student > Ph. D. Student | 15 | 21% |
| Student > Bachelor | 9 | 13% |
| Student > Master | 5 | 7% |
| Other | 5 | 7% |
| Other | 7 | 10% |
| Unknown | 7 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 24% |
| Biochemistry, Genetics and Molecular Biology | 11 | 16% |
| Chemistry | 11 | 16% |
| Medicine and Dentistry | 8 | 11% |
| Neuroscience | 6 | 9% |
| Other | 7 | 10% |
| Unknown | 10 | 14% |