Title |
Metabolomics of Dietary Fatty Acid Restriction in Patients with Phenylketonuria
|
---|---|
Published in |
PLOS ONE, August 2012
|
DOI | 10.1371/journal.pone.0043021 |
Pubmed ID | |
Authors |
Ulrike Mütze, Skadi Beblo, Linda Kortz, Claudia Matthies, Berthold Koletzko, Mathias Bruegel, Carmen Rohde, Joachim Thiery, Wieland Kiess, Uta Ceglarek |
Abstract |
Patients with phenylketonuria (PKU) have to follow a lifelong phenylalanine restricted diet. This type of diet markedly reduces the intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LC-PUFA). Long-chain saturated fatty acids are substrates of mitochondrial fatty acid oxidation for acetyl-CoA production. LC-PUFA are discussed to affect inflammatory and haemostaseological processes in health and disease. The influence of the long term PKU diet on fatty acid metabolism with a special focus on platelet eicosanoid metabolism has been investigated in the study presented here. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Netherlands | 2 | 50% |
United States | 1 | 25% |
Unknown | 1 | 25% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 4 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 60 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 16% |
Student > Master | 10 | 16% |
Researcher | 9 | 15% |
Student > Bachelor | 5 | 8% |
Other | 3 | 5% |
Other | 7 | 11% |
Unknown | 17 | 28% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 20% |
Medicine and Dentistry | 10 | 16% |
Biochemistry, Genetics and Molecular Biology | 6 | 10% |
Chemistry | 4 | 7% |
Nursing and Health Professions | 3 | 5% |
Other | 7 | 11% |
Unknown | 19 | 31% |