| Title |
HIV-1 Envelope Resistance to Proteasomal Cleavage: Implications for Vaccine Induced Immune Responses
|
|---|---|
| Published in |
PLOS ONE, August 2012
|
| DOI | 10.1371/journal.pone.0042579 |
| Pubmed ID | |
| Authors |
Nicholas J. Steers, Silvia Ratto-Kim, Mark S. de Souza, Jeffrey R. Currier, Jerome H. Kim, Nelson L. Michael, Carl R. Alving, Mangala Rao |
| Abstract |
Antigen processing involves many proteolytic enzymes such as proteasomes and cathepsins. The processed antigen is then presented on the cell surface bound to either MHC class I or class II molecules and induces/interacts with antigen-specific CD8+ and CD4+ T-cells, respectively. Preliminary immunological data from the RV144 phase III trial indicated that the immune responses were biased towards the Env antigen with a dominant CD4+ T-cell response. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 34% |
| Student > Master | 5 | 17% |
| Student > Ph. D. Student | 5 | 17% |
| Other | 2 | 7% |
| Student > Bachelor | 2 | 7% |
| Other | 4 | 14% |
| Unknown | 1 | 3% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 28% |
| Immunology and Microbiology | 6 | 21% |
| Medicine and Dentistry | 5 | 17% |
| Biochemistry, Genetics and Molecular Biology | 3 | 10% |
| Chemistry | 3 | 10% |
| Other | 2 | 7% |
| Unknown | 2 | 7% |