Title |
Pertussis Circulation Has Increased T-Cell Immunity during Childhood More than a Second Acellular Booster Vaccination in Dutch Children 9 Years of Age
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Published in |
PLOS ONE, July 2012
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DOI | 10.1371/journal.pone.0041928 |
Pubmed ID | |
Authors |
Rose-Minke Schure, Lia de Rond, Kemal Öztürk, Lotte Hendrikx, Elisabeth Sanders, Guy Berbers, Anne-Marie Buisman |
Abstract |
Here we report the first evaluation of T-cell responses upon a second acellular pertussis booster vaccination in Dutch children at 9 years of age, 5 years after a preschool booster vaccination. Blood samples of children 9 years of age were studied longitudinally until 1 year after the second aP booster and compared with those after the first aP booster in children 4 and 6 years of age from a cross-sectional study. After stimulation with pertussis-vaccine antigens, Th1, Th2 and Th17 cytokine responses were measured and effector memory cells (CCR7-CD45RA-) were characterized by 8-colour FACS analysis. The second aP booster vaccination at pre-adolescent age in wP primed individuals did increase pertussis-specific Th1 and Th2 cytokine responses. Noticeably, almost all T-cell responses had increased with age and were already high before the booster vaccination at 9 years of age. The enhancement of T-cell immunity during the 5 year following the booster at 4 years of age is probably caused by natural boosting due to the a high circulation of pertussis. However, the incidence of pertussis is high in adolescents and adults who have only received the Dutch wP vaccine during infancy and no booster at 4 years of age. Therefore, an aP booster vaccination at adolescence or later in these populations might improve long-term immunity against pertussis and reduce the transmission to the vulnerable newborns. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 2 | 5% |
United States | 1 | 3% |
France | 1 | 3% |
Australia | 1 | 3% |
Unknown | 32 | 86% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 7 | 19% |
Researcher | 7 | 19% |
Student > Master | 5 | 14% |
Professor | 2 | 5% |
Student > Bachelor | 2 | 5% |
Other | 7 | 19% |
Unknown | 7 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 10 | 27% |
Agricultural and Biological Sciences | 9 | 24% |
Immunology and Microbiology | 4 | 11% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Arts and Humanities | 1 | 3% |
Other | 2 | 5% |
Unknown | 10 | 27% |