| Title |
Exercise Training Prevents Oxidative Stress and Ubiquitin-Proteasome System Overactivity and Reverse Skeletal Muscle Atrophy in Heart Failure
|
|---|---|
| Published in |
PLOS ONE, August 2012
|
| DOI | 10.1371/journal.pone.0041701 |
| Pubmed ID | |
| Authors |
Telma F. Cunha, Aline V. N. Bacurau, Jose B. N. Moreira, Nathalie A. Paixão, Juliane C. Campos, Julio C. B. Ferreira, Marcelo L. Leal, Carlos E. Negrão, Anselmo S. Moriscot, Ulrik Wisløff, Patricia C. Brum |
| Abstract |
Heart failure (HF) is known to lead to skeletal muscle atrophy and dysfunction. However, intracellular mechanisms underlying HF-induced myopathy are not fully understood. We hypothesized that HF would increase oxidative stress and ubiquitin-proteasome system (UPS) activation in skeletal muscle of sympathetic hyperactivity mouse model. We also tested the hypothesis that aerobic exercise training (AET) would reestablish UPS activation in mice and human HF. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 181 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 6 | 3% |
| United States | 2 | 1% |
| Indonesia | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 171 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 22 | 12% |
| Student > Bachelor | 20 | 11% |
| Researcher | 19 | 10% |
| Student > Ph. D. Student | 19 | 10% |
| Student > Doctoral Student | 14 | 8% |
| Other | 48 | 27% |
| Unknown | 39 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 19% |
| Agricultural and Biological Sciences | 33 | 18% |
| Nursing and Health Professions | 24 | 13% |
| Biochemistry, Genetics and Molecular Biology | 16 | 9% |
| Sports and Recreations | 16 | 9% |
| Other | 18 | 10% |
| Unknown | 40 | 22% |