| Title |
Association of the Maternal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects in Offsprings: Evidence from 25 Case-Control Studies
|
|---|---|
| Published in |
PLOS ONE, October 2012
|
| DOI | 10.1371/journal.pone.0041689 |
| Pubmed ID | |
| Authors |
Lifeng Yan, Lin Zhao, Yan Long, Peng Zou, Guixiang Ji, Aihua Gu, Peng Zhao |
| Abstract |
Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA methylation, DNA synthesis, and DNA repair. In addition, it is a possible risk factor in neural tube defects (NTDs). The association of the C677T polymorphism in the MTHFR gene and NTD susceptibility has been widely demonstrated, but the results remain inconclusive. In this study, we performed a meta-analysis with 2429 cases and 3570 controls to investigate the effect of the MTHFR C677T polymorphism on NTDs. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 114 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Unknown | 113 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 33 | 29% |
| Student > Master | 22 | 19% |
| Student > Postgraduate | 8 | 7% |
| Student > Ph. D. Student | 8 | 7% |
| Student > Doctoral Student | 7 | 6% |
| Other | 23 | 20% |
| Unknown | 13 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 32 | 28% |
| Biochemistry, Genetics and Molecular Biology | 21 | 18% |
| Agricultural and Biological Sciences | 20 | 18% |
| Nursing and Health Professions | 8 | 7% |
| Neuroscience | 5 | 4% |
| Other | 11 | 10% |
| Unknown | 17 | 15% |