| Title |
Cytosolic Entry of Shiga-Like Toxin A Chain from the Yeast Endoplasmic Reticulum Requires Catalytically Active Hrd1p
|
|---|---|
| Published in |
PLOS ONE, July 2012
|
| DOI | 10.1371/journal.pone.0041119 |
| Pubmed ID | |
| Authors |
Shuyu Li, Robert A. Spooner, Randolph Y. Hampton, J. Michael Lord, Lynne M. Roberts |
| Abstract |
Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes. Currently, no molecular details of the dislocation process are available. To investigate the mechanism of the dislocation step we expressed SLTxA1 in the ER of Saccharomyces cerevisiae. |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 40% |
| Researcher | 5 | 33% |
| Student > Bachelor | 2 | 13% |
| Student > Master | 1 | 7% |
| Professor | 1 | 7% |
| Other | 0 | 0% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 47% |
| Biochemistry, Genetics and Molecular Biology | 6 | 40% |
| Chemistry | 1 | 7% |
| Engineering | 1 | 7% |