| Title |
Mycobacterium tuberculosis Complex Enhances Susceptibility of CD4 T Cells to HIV through a TLR2-Mediated Pathway
|
|---|---|
| Published in |
PLOS ONE, July 2012
|
| DOI | 10.1371/journal.pone.0041093 |
| Pubmed ID | |
| Authors |
Seema M. Thayil, Ya-Chi Ho, Robert C. Bollinger, Joel N. Blankson, Robert F. Siliciano, Petros C. Karakousis, Kathleen R. Page |
| Abstract |
Among HIV-infected individuals, co-infection with Mycobacterium tuberculosis is associated with faster progression to AIDS. We investigated the hypothesis that M. bovis BCG and M. tuberculosis (Mtb complex) could enhance susceptibility of CD4+ cells to HIV infection. Peripheral blood mononuclear cells (PBMCs) collected from healthy donors were stimulated with M. bovis BCG, M. tuberculosis CDC1551 and M. smegmatis MC(2)155, and stimulated CD4+ cells were infected with R5-and X4-tropic single replication-competent pseudovirus. CD4+ cells stimulated with Mtb complex showed enhanced infection with R5- and X4-tropic HIV, compared to unstimulated cells or cells stimulated with M. smegmatis (p<0.01). Treatment with TLR2 siRNA reversed the increased susceptibility of CD4+ cells with R5- and X4-tropic virus induced by Mtb complex. These findings suggest that TB infection and/or BCG vaccination may be a risk factor for HIV acquisition. |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Norway | 1 | 2% |
| South Africa | 1 | 2% |
| Unknown | 48 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 18% |
| Student > Master | 8 | 16% |
| Researcher | 7 | 14% |
| Student > Bachelor | 6 | 12% |
| Student > Doctoral Student | 4 | 8% |
| Other | 10 | 20% |
| Unknown | 7 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 31% |
| Biochemistry, Genetics and Molecular Biology | 8 | 16% |
| Medicine and Dentistry | 8 | 16% |
| Immunology and Microbiology | 5 | 10% |
| Social Sciences | 2 | 4% |
| Other | 6 | 12% |
| Unknown | 6 | 12% |