| Title |
The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background
|
|---|---|
| Published in |
PLOS ONE, July 2012
|
| DOI | 10.1371/journal.pone.0040972 |
| Pubmed ID | |
| Authors |
Lynley D. Pound, Suparna A. Sarkar, Alessandro Ustione, Prasanna K. Dadi, Melanie K. Shadoan, Catherine E. Lee, Jay A. Walters, Masakazu Shiota, Owen P. McGuinness, David A. Jacobson, David W. Piston, John C. Hutton, David R. Powell, Richard M. O’Brien |
| Abstract |
The SLC30A8 gene encodes the islet-specific transporter ZnT-8, which is hypothesized to provide zinc for insulin-crystal formation. A polymorphic variant in SLC30A8 is associated with altered susceptibility to type 2 diabetes. Several groups have examined the effect of global Slc30a8 gene deletion but the results have been highly variable, perhaps due to the mixed 129SvEv/C57BL/6J genetic background of the mice studied. We therefore sought to remove the conflicting effect of 129SvEv-specific modifier genes. |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 27% |
| Researcher | 12 | 21% |
| Student > Master | 7 | 13% |
| Student > Bachelor | 6 | 11% |
| Other | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 7 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 16 | 29% |
| Agricultural and Biological Sciences | 14 | 25% |
| Medicine and Dentistry | 9 | 16% |
| Immunology and Microbiology | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 5 | 9% |
| Unknown | 9 | 16% |