| Title |
A Comparison of Gene Region Simulation Methods
|
|---|---|
| Published in |
PLOS ONE, July 2012
|
| DOI | 10.1371/journal.pone.0040925 |
| Pubmed ID | |
| Authors |
Audrey E. Hendricks, Josée Dupuis, Mayetri Gupta, Mark W. Logue, Kathryn L. Lunetta |
| Abstract |
Accurately modeling LD in simulations is essential to correctly evaluate new and existing association methods. At present, there has been minimal research comparing the quality of existing gene region simulation methods to produce LD structures similar to an existing gene region. Here we compare the ability of three approaches to accurately simulate the LD within a gene region: HapSim (2005), Hapgen (2009), and a minor extension to simple haplotype resampling. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 10% |
| United States | 1 | 5% |
| Unknown | 18 | 86% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 52% |
| Student > Doctoral Student | 2 | 10% |
| Student > Ph. D. Student | 2 | 10% |
| Student > Master | 2 | 10% |
| Lecturer > Senior Lecturer | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 1 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 5 | 24% |
| Medicine and Dentistry | 4 | 19% |
| Mathematics | 3 | 14% |
| Biochemistry, Genetics and Molecular Biology | 3 | 14% |
| Computer Science | 3 | 14% |
| Other | 1 | 5% |
| Unknown | 2 | 10% |