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Prediction of HLA Class II Alleles Using SNPs in an African Population

Overview of attention for article published in PLOS ONE, June 2012
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Title
Prediction of HLA Class II Alleles Using SNPs in an African Population
Published in
PLOS ONE, June 2012
DOI 10.1371/journal.pone.0040206
Pubmed ID
Authors

Fasil Tekola Ayele, Elena Hailu, Chris Finan, Abraham Aseffa, Gail Davey, Melanie J. Newport, Charles N. Rotimi, Adebowale Adeyemo

Abstract

Despite the importance of the human leukocyte antigen (HLA) gene locus in research and clinical practice, direct HLA typing is laborious and expensive. Furthermore, the analysis requires specialized software and expertise which are unavailable in most developing country settings. Recently, in silico methods have been developed for predicting HLA alleles using single nucleotide polymorphisms (SNPs). However, the utility of these methods in African populations has not been systematically evaluated.

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Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 3%
France 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 31%
Student > Ph. D. Student 7 20%
Student > Postgraduate 3 9%
Student > Master 3 9%
Professor > Associate Professor 2 6%
Other 6 17%
Unknown 3 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 11 31%
Biochemistry, Genetics and Molecular Biology 7 20%
Medicine and Dentistry 5 14%
Immunology and Microbiology 3 9%
Computer Science 2 6%
Other 0 0%
Unknown 7 20%