| Title |
Adjunctive TNF Inhibition with Standard Treatment Enhances Bacterial Clearance in a Murine Model of Necrotic TB Granulomas
|
|---|---|
| Published in |
PLOS ONE, June 2012
|
| DOI | 10.1371/journal.pone.0039680 |
| Pubmed ID | |
| Authors |
Ciaran Skerry, Jamie Harper, Mariah Klunk, William R. Bishai, Sanjay K. Jain |
| Abstract |
It has been hypothesized that early host-responses during TB treatment may paradoxically promote survival of persistent bacteria. We therefore evaluated whether adjunctive inhibition of tumor necrosis factor alpha (TNF-α)-a key cytokine in host responses against TB-could hasten bacterial clearance in a mouse strain that develops necrotic lesions in response to Mycobacterium tuberculosis infection. |
Mendeley readers
The data shown below were compiled from readership statistics for 82 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Unknown | 81 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 21 | 26% |
| Student > Ph. D. Student | 15 | 18% |
| Student > Doctoral Student | 9 | 11% |
| Other | 8 | 10% |
| Professor | 5 | 6% |
| Other | 15 | 18% |
| Unknown | 9 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 17 | 21% |
| Immunology and Microbiology | 14 | 17% |
| Medicine and Dentistry | 14 | 17% |
| Biochemistry, Genetics and Molecular Biology | 9 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 9% |
| Other | 4 | 5% |
| Unknown | 17 | 21% |