Title |
Neighbor Overlap Is Enriched in the Yeast Interaction Network: Analysis and Implications
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Published in |
PLOS ONE, June 2012
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DOI | 10.1371/journal.pone.0039662 |
Pubmed ID | |
Authors |
Ariel Feiglin, John Moult, Byungkook Lee, Yanay Ofran, Ron Unger |
Abstract |
The yeast protein-protein interaction network has been shown to have distinct topological features such as a scale free degree distribution and a high level of clustering. Here we analyze an additional feature which is called Neighbor Overlap. This feature reflects the number of shared neighbors between a pair of proteins. We show that Neighbor Overlap is enriched in the yeast protein-protein interaction network compared with control networks carefully designed to match the characteristics of the yeast network in terms of degree distribution and clustering coefficient. Our analysis also reveals that pairs of proteins with high Neighbor Overlap have higher sequence similarity, more similar GO annotations and stronger genetic interactions than pairs with low ones. Finally, we demonstrate that pairs of proteins with redundant functions tend to have high Neighbor Overlap. We suggest that a combination of three mechanisms is the basis for this feature: The abundance of protein complexes, selection for backup of function, and the need to allow functional variation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 7% |
Germany | 1 | 7% |
Unknown | 13 | 87% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 33% |
Professor | 3 | 20% |
Researcher | 2 | 13% |
Student > Bachelor | 1 | 7% |
Unspecified | 1 | 7% |
Other | 2 | 13% |
Unknown | 1 | 7% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 53% |
Biochemistry, Genetics and Molecular Biology | 3 | 20% |
Computer Science | 1 | 7% |
Unspecified | 1 | 7% |
Unknown | 2 | 13% |