Title |
Alopecia in a Viable Phospholipase C Delta 1 and Phospholipase C Delta 3 Double Mutant
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Published in |
PLOS ONE, June 2012
|
DOI | 10.1371/journal.pone.0039203 |
Pubmed ID | |
Authors |
Fabian Runkel, Maik Hintze, Sebastian Griesing, Marion Michels, Birgit Blanck, Kiyoko Fukami, Jean-Louis Guénet, Thomas Franz |
Abstract |
Inositol 1,4,5trisphosphate (IP(3)) and diacylglycerol (DAG) are important intracellular signalling molecules in various tissues. They are generated by the phospholipase C family of enzymes, of which phospholipase C delta (PLCD) forms one class. Studies with functional inactivation of Plcd isozyme encoding genes in mice have revealed that loss of both Plcd1 and Plcd3 causes early embryonic death. Inactivation of Plcd1 alone causes loss of hair (alopecia), whereas inactivation of Plcd3 alone has no apparent phenotypic effect. To investigate a possible synergy of Plcd1 and Plcd3 in postnatal mice, novel mutations of these genes compatible with life after birth need to be found. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 18% |
Researcher | 2 | 18% |
Librarian | 1 | 9% |
Student > Master | 1 | 9% |
Lecturer | 1 | 9% |
Other | 2 | 18% |
Unknown | 2 | 18% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 4 | 36% |
Agricultural and Biological Sciences | 3 | 27% |
Nursing and Health Professions | 1 | 9% |
Social Sciences | 1 | 9% |
Biochemistry, Genetics and Molecular Biology | 1 | 9% |
Other | 0 | 0% |
Unknown | 1 | 9% |