Title |
Low Immune Response to Hepatitis B Vaccine among Children in Dakar, Senegal
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Published in |
PLOS ONE, May 2012
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DOI | 10.1371/journal.pone.0038153 |
Pubmed ID | |
Authors |
Marie-Anne Rey-Cuille, Abdoulaye Seck, Richard Njouom, Loïc Chartier, Housseyn Dembel Sow, Mamadou, Amadou Sidy Ka, Mohamadou Njankouo, Dominique Rousset, Tamara Giles-Vernick, Guillemette Unal, Jean-Marie Sire, Benoît Garin, François Simon, Muriel Vray |
Abstract |
HBV vaccine was introduced into the Expanded Programme on Immunization (EPI) in Senegal and Cameroon in 2005. We conducted a cross-sectional study in both countries to assess the HBV immune protection among children. All consecutive children under 4 years old, hospitalized for any reason between May 2009 and May 2010, with an immunisation card and a complete HBV vaccination, were tested for anti-HBs and anti-HBc. A total of 242 anti-HBc-negative children (128 in Cameroon and 114 in Senegal) were considered in the analysis. The prevalence of children with anti-HBs ≥ 10 IU/L was higher in Cameroon with 92% (95% CI: 87%-97%) compared to Senegal with 58% (95% CI: 49%-67%), (p<0.001). The response to vaccination in Senegal was lower in 2006-2007 (43%) than in 2008-2009 (65%), (p = 0.028). Our results, although not based on a representative sample of Senegalese or Cameroonian child populations, reveal a significant problem in vaccine response in Senegal. This response problem extends well beyond hepatitis B: the same children who have not developed an immune response to the HBV vaccine are also at risk for diphtheria, tetanus, pertussis (DTwP) and Haemophilus influenzae type b (Hib). Field biological monitoring should be carried out regularly in resource-poor countries to check quality of the vaccine administered. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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France | 2 | 3% |
United Kingdom | 1 | 1% |
Unknown | 76 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 19 | 24% |
Researcher | 14 | 18% |
Student > Ph. D. Student | 8 | 10% |
Student > Bachelor | 5 | 6% |
Other | 5 | 6% |
Other | 12 | 15% |
Unknown | 16 | 20% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 32 | 41% |
Agricultural and Biological Sciences | 7 | 9% |
Social Sciences | 5 | 6% |
Nursing and Health Professions | 4 | 5% |
Biochemistry, Genetics and Molecular Biology | 4 | 5% |
Other | 7 | 9% |
Unknown | 20 | 25% |