| Title |
Gender Differences in Associations of Glutamate Decarboxylase 1 Gene (GAD1) Variants with Panic Disorder
|
|---|---|
| Published in |
PLOS ONE, May 2012
|
| DOI | 10.1371/journal.pone.0037651 |
| Pubmed ID | |
| Authors |
Heike Weber, Claus Jürgen Scholz, Katharina Domschke, Christian Baumann, Benedikt Klauke, Christian P. Jacob, Wolfgang Maier, Jürgen Fritze, Borwin Bandelow, Peter Michael Zwanzger, Thomas Lang, Lydia Fehm, Andreas Ströhle, Alfons Hamm, Alexander L. Gerlach, Georg W. Alpers, Tilo Kircher, Hans-Ulrich Wittchen, Volker Arolt, Paul Pauli, Jürgen Deckert, Andreas Reif |
| Abstract |
Panic disorder is common (5% prevalence) and females are twice as likely to be affected as males. The heritable component of panic disorder is estimated at 48%. Glutamic acid dehydrogenase GAD1, the key enzyme for the synthesis of the inhibitory and anxiolytic neurotransmitter GABA, is supposed to influence various mental disorders, including mood and anxiety disorders. In a recent association study in depression, which is highly comorbid with panic disorder, GAD1 risk allele associations were restricted to females. |
Mendeley readers
The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 3 | 6% |
| Hungary | 1 | 2% |
| Unknown | 46 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 22% |
| Student > Master | 6 | 12% |
| Student > Ph. D. Student | 6 | 12% |
| Professor | 4 | 8% |
| Student > Bachelor | 3 | 6% |
| Other | 9 | 18% |
| Unknown | 11 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 15 | 30% |
| Medicine and Dentistry | 13 | 26% |
| Agricultural and Biological Sciences | 4 | 8% |
| Neuroscience | 3 | 6% |
| Biochemistry, Genetics and Molecular Biology | 2 | 4% |
| Other | 0 | 0% |
| Unknown | 13 | 26% |