| Title |
Bone Marrow Stromal Cells Modulate Mouse ENT1 Activity and Protect Leukemia Cells from Cytarabine Induced Apoptosis
|
|---|---|
| Published in |
PLOS ONE, May 2012
|
| DOI | 10.1371/journal.pone.0037203 |
| Pubmed ID | |
| Authors |
Patricia Macanas-Pirard, Andrea Leisewitz, Richard Broekhuizen, Kelly Cautivo, Francisco M. Barriga, Francisco Leisewitz, Victoria Gidi, Erick Riquelme, Viviana P. Montecinos, Pilar Swett, Pelayo Besa, Pablo Ramirez, Mauricio Ocqueteau, Alexis M. Kalergis, Matthew Holt, Michael Rettig, John F. DiPersio, Bruno Nervi |
| Abstract |
Despite a high response rate to chemotherapy, the majority of patients with acute myeloid leukemia (AML) are destined to relapse due to residual disease in the bone marrow (BM). The tumor microenvironment is increasingly being recognized as a critical factor in mediating cancer cell survival and drug resistance. In this study, we propose to identify mechanisms involved in the chemoprotection conferred by the BM stroma to leukemia cells. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 21% |
| Student > Ph. D. Student | 11 | 20% |
| Researcher | 4 | 7% |
| Student > Bachelor | 4 | 7% |
| Student > Postgraduate | 4 | 7% |
| Other | 10 | 18% |
| Unknown | 11 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 29% |
| Medicine and Dentistry | 11 | 20% |
| Biochemistry, Genetics and Molecular Biology | 8 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Psychology | 2 | 4% |
| Other | 2 | 4% |
| Unknown | 15 | 27% |