| Title |
Paraoxonase 1 Polymorphism and Prenatal Pesticide Exposure Associated with Adverse Cardiovascular Risk Profiles at School Age
|
|---|---|
| Published in |
PLOS ONE, May 2012
|
| DOI | 10.1371/journal.pone.0036830 |
| Pubmed ID | |
| Authors |
Helle R. Andersen, Christine Wohlfahrt-Veje, Christine Dalgård, Lene Christiansen, Katharina M. Main, Christine Nellemann, Katsuyuki Murata, Tina K. Jensen, Niels E. Skakkebæk, Philippe Grandjean |
| Abstract |
Prenatal environmental factors might influence the risk of developing cardiovascular disease later in life. The HDL-associated enzyme paraoxonase 1 (PON1) has anti-oxidative functions that may protect against atherosclerosis. It also hydrolyzes many substrates, including organophosphate pesticides. A common polymorphism, PON1 Q192R, affects both properties, but a potential interaction between PON1 genotype and pesticide exposure on cardiovascular risk factors has not been investigated. We explored if the PON1 Q192R genotype affects cardiovascular risk factors in school-age children prenatally exposed to pesticides. |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Denmark | 2 | 2% |
| Malaysia | 1 | 1% |
| Chile | 1 | 1% |
| Spain | 1 | 1% |
| Unknown | 85 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 14% |
| Student > Master | 13 | 14% |
| Researcher | 12 | 13% |
| Student > Bachelor | 11 | 12% |
| Professor | 6 | 7% |
| Other | 17 | 19% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 18% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Agricultural and Biological Sciences | 9 | 10% |
| Nursing and Health Professions | 7 | 8% |
| Psychology | 6 | 7% |
| Other | 16 | 18% |
| Unknown | 24 | 27% |