| Title |
Deep Brain Stimulation of Nucleus Accumbens Region in Alcoholism Affects Reward Processing
|
|---|---|
| Published in |
PLOS ONE, May 2012
|
| DOI | 10.1371/journal.pone.0036572 |
| Pubmed ID | |
| Authors |
Marcus Heldmann, Georg Berding, Jürgen Voges, Bernhard Bogerts, Imke Galazky, Ulf Müller, Gunther Baillot, Hans-Jochen Heinze, Thomas F. Münte |
| Abstract |
The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H(2)[(15)O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed a less risky, more careful choice behavior under active DBS compared to DBS switched off. PET showed win- and loss-related activations in the paracingulate cortex, temporal poles, precuneus and hippocampus under active DBS, brain areas that have been implicated in action monitoring and behavioral control. Except for the temporal pole these activations were not seen when DBS was deactivated. These findings suggest that DBS of the NAcc may act partially by improving behavioral control. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Egypt | 2 | 20% |
| Chile | 1 | 10% |
| Canada | 1 | 10% |
| United States | 1 | 10% |
| United Kingdom | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Scientists | 2 | 20% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 1% |
| France | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 89 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 18% |
| Student > Ph. D. Student | 14 | 15% |
| Researcher | 13 | 14% |
| Other | 8 | 9% |
| Student > Master | 6 | 7% |
| Other | 14 | 15% |
| Unknown | 20 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 25% |
| Psychology | 20 | 22% |
| Neuroscience | 8 | 9% |
| Agricultural and Biological Sciences | 7 | 8% |
| Engineering | 4 | 4% |
| Other | 6 | 7% |
| Unknown | 24 | 26% |