| Title |
Glucose-Dependent Regulation of NR2F2 Promoter and Influence of SNP-rs3743462 on Whole Body Insulin Sensitivity
|
|---|---|
| Published in |
PLOS ONE, May 2012
|
| DOI | 10.1371/journal.pone.0035810 |
| Pubmed ID | |
| Authors |
Marie Boutant, Oscar Henrique Pereira Ramos, Cécile Lecoeur, Emmanuel Vaillant, Julien Philippe, Pili Zhang, Anaïs Perilhou, Beatriz Valcarcel, Sylvain Sebert, Mario-Ritta Jarvelin, Beverley Balkau, Donald Scott, Philippe Froguel, Martine Vaxillaire, Mireille Vasseur-Cognet |
| Abstract |
The Nuclear Receptor 2F2 (NR2F2/COUP-TFII) heterozygous knockout mice display low basal insulinemia and enhanced insulin sensitivity. We previously established that insulin represses NR2F2 gene expression in pancreatic β-cells. The cis-regulatory region of the NR2F2 promoter is unknown and its influence on metabolism in humans is poorly understood. The present study aimed to identify the regulatory regions that control NR2F2 gene transcription and to evaluate the effect of NR2F2 promoter variation on glucose homeostasis in humans. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 1 | 50% |
| India | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 27 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 22% |
| Professor | 5 | 19% |
| Student > Postgraduate | 3 | 11% |
| Student > Master | 3 | 11% |
| Student > Ph. D. Student | 3 | 11% |
| Other | 4 | 15% |
| Unknown | 3 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 26% |
| Medicine and Dentistry | 6 | 22% |
| Biochemistry, Genetics and Molecular Biology | 5 | 19% |
| Engineering | 2 | 7% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 4 | 15% |