| Title |
A Novel Network Integrating a miRNA-203/SNAI1 Feedback Loop which Regulates Epithelial to Mesenchymal Transition
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0035440 |
| Pubmed ID | |
| Authors |
Michèle Moes, Antony Le Béchec, Isaac Crespo, Christina Laurini, Aliaksandr Halavatyi, Guillaume Vetter, Antonio del Sol, Evelyne Friederich |
| Abstract |
The majority of human cancer deaths are caused by metastasis. The metastatic dissemination is initiated by the breakdown of epithelial cell homeostasis. During this phenomenon, referred to as epithelial to mesenchymal transition (EMT), cells change their genetic and trancriptomic program leading to phenotypic and functional alterations. The challenge of understanding this dynamic process resides in unraveling regulatory networks involving master transcription factors (e.g. SNAI1/2, ZEB1/2 and TWIST1) and microRNAs. Here we investigated microRNAs regulated by SNAI1 and their potential role in the regulatory networks underlying epithelial plasticity. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 148 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 1% |
| United States | 2 | 1% |
| Italy | 1 | <1% |
| Bangladesh | 1 | <1% |
| France | 1 | <1% |
| Luxembourg | 1 | <1% |
| Unknown | 140 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 38 | 26% |
| Student > Ph. D. Student | 33 | 22% |
| Student > Master | 25 | 17% |
| Student > Bachelor | 16 | 11% |
| Professor > Associate Professor | 10 | 7% |
| Other | 18 | 12% |
| Unknown | 8 | 5% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 70 | 47% |
| Biochemistry, Genetics and Molecular Biology | 30 | 20% |
| Medicine and Dentistry | 17 | 11% |
| Engineering | 9 | 6% |
| Computer Science | 3 | 2% |
| Other | 6 | 4% |
| Unknown | 13 | 9% |