| Title |
Germline BAP1 Inactivation Is Preferentially Associated with Metastatic Ocular Melanoma and Cutaneous-Ocular Melanoma Families
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0035295 |
| Pubmed ID | |
| Authors |
Ching-Ni Jenny Njauw, Ivana Kim, Adriano Piris, Michele Gabree, Michael Taylor, Anne Marie Lane, Margaret M. DeAngelis, Evangelos Gragoudas, Lyn M. Duncan, Hensin Tsao |
| Abstract |
BAP1 has been shown to be a target of both somatic alteration in high-risk ocular melanomas (OM) and germline inactivation in a few individuals from cancer-prone families. These findings suggest that constitutional BAP1 changes may predispose individuals to metastatic OM and that familial permeation of deleterious alleles could delineate a new cancer syndrome. |
Mendeley readers
The data shown below were compiled from readership statistics for 111 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 111 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 18% |
| Student > Ph. D. Student | 17 | 15% |
| Student > Bachelor | 12 | 11% |
| Other | 10 | 9% |
| Student > Doctoral Student | 8 | 7% |
| Other | 24 | 22% |
| Unknown | 20 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 39 | 35% |
| Agricultural and Biological Sciences | 22 | 20% |
| Biochemistry, Genetics and Molecular Biology | 20 | 18% |
| Mathematics | 2 | 2% |
| Computer Science | 2 | 2% |
| Other | 4 | 4% |
| Unknown | 22 | 20% |