| Title |
Repertoire Enhancement with Adoptively Transferred Female Lymphocytes Controls the Growth of Pre-Implanted Murine Prostate Cancer
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0035222 |
| Pubmed ID | |
| Authors |
Robert R. Jenq, Michael A. Curran, Gabrielle L. Goldberg, Chen Liu, James P. Allison, Marcel R. M. van den Brink |
| Abstract |
In prostate cancer, genes encoding androgen-regulated, Y-chromosome-encoded, and tissue-specific antigens may all be overexpressed. In the adult male host, however, most high affinity T cells targeting these potential tumor rejection antigens will be removed during negative selection. In contrast, the female mature T-cell repertoire should contain abundant precursors capable of recognizing these classes of prostate cancer antigens and mediating effective anti-tumor immune responses. |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 21% |
| Librarian | 3 | 11% |
| Professor > Associate Professor | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Student > Master | 2 | 7% |
| Other | 5 | 18% |
| Unknown | 7 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 29% |
| Medicine and Dentistry | 6 | 21% |
| Immunology and Microbiology | 3 | 11% |
| Computer Science | 1 | 4% |
| Unspecified | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 7 | 25% |