| Title |
Enhancement of Cell-Based Therapeutic Angiogenesis Using a Novel Type of Injectable Scaffolds of Hydroxyapatite-Polymer Nanocomposite Microspheres
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0035199 |
| Pubmed ID | |
| Authors |
Yohei Mima, Shinya Fukumoto, Hidenori Koyama, Masahiro Okada, Shinji Tanaka, Tetsuo Shoji, Masanori Emoto, Tsutomu Furuzono, Yoshiki Nishizawa, Masaaki Inaba |
| Abstract |
Clinical trials demonstrate the effectiveness of cell-based therapeutic angiogenesis in patients with severe ischemic diseases; however, their success remains limited. Maintaining transplanted cells in place are expected to augment the cell-based therapeutic angiogenesis. We have reported that nano-hydroxyapatite (HAp) coating on medical devices shows marked cell adhesiveness. Using this nanotechnology, HAp-coated poly(l-lactic acid) (PLLA) microspheres, named nano-scaffold (NS), were generated as a non-biological, biodegradable and injectable cell scaffold. We investigate the effectiveness of NS on cell-based therapeutic angiogenesis. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| Latvia | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 89 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 28% |
| Student > Master | 14 | 15% |
| Student > Bachelor | 12 | 13% |
| Researcher | 7 | 8% |
| Professor > Associate Professor | 7 | 8% |
| Other | 12 | 13% |
| Unknown | 14 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 24% |
| Engineering | 16 | 17% |
| Agricultural and Biological Sciences | 14 | 15% |
| Materials Science | 6 | 7% |
| Chemistry | 4 | 4% |
| Other | 12 | 13% |
| Unknown | 18 | 20% |