| Title |
Rational Incorporation of Selenium into Temozolomide Elicits Superior Antitumor Activity Associated with Both Apoptotic and Autophagic Cell Death
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0035104 |
| Pubmed ID | |
| Authors |
Yan Cheng, Ugir Hossain Sk, Yi Zhang, Xingcong Ren, Li Zhang, Kathryn J. Huber-Keener, Yuan-Wan Sun, Jason Liao, Shantu Amin, Arun K. Sharma, Jin-Ming Yang |
| Abstract |
The DNA alkylating agent temozolomide (TMZ) is widely used in the treatment of human malignancies such as glioma and melanoma. On the basis of previous structure-activity studies, we recently synthesized a new TMZ selenium analog by rationally introducing an N-ethylselenocyanate extension to the amide functionality in TMZ structure. |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 7 | 19% |
| Student > Master | 6 | 16% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Postgraduate | 3 | 8% |
| Student > Bachelor | 3 | 8% |
| Other | 6 | 16% |
| Unknown | 7 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 27% |
| Biochemistry, Genetics and Molecular Biology | 7 | 19% |
| Agricultural and Biological Sciences | 4 | 11% |
| Chemistry | 4 | 11% |
| Immunology and Microbiology | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 9 | 24% |