| Title |
Comparative Study on the Therapeutic Potential of Neurally Differentiated Stem Cells in a Mouse Model of Multiple Sclerosis
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0035093 |
| Pubmed ID | |
| Authors |
Natalie L. Payne, Guizhi Sun, Daniella Herszfeld, Pollyanna A. Tat-Goh, Paul J. Verma, Helena C. Parkington, Harold A. Coleman, Mary A. Tonta, Christopher Siatskas, Claude C. A. Bernard |
| Abstract |
Transplantation of neural stem cells (NSCs) is a promising novel approach to the treatment of neuroinflammatory diseases such as multiple sclerosis (MS). NSCs can be derived from primary central nervous system (CNS) tissue or obtained by neural differentiation of embryonic stem (ES) cells, the latter having the advantage of readily providing an unlimited number of cells for therapeutic purposes. Using a mouse model of MS, we evaluated the therapeutic potential of NSCs derived from ES cells by two different neural differentiation protocols that utilized adherent culture conditions and compared their effect to primary NSCs derived from the subventricular zone (SVZ). |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Egypt | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| United States | 1 | 2% |
| Portugal | 1 | 2% |
| Unknown | 53 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 19% |
| Researcher | 11 | 19% |
| Student > Bachelor | 8 | 14% |
| Student > Postgraduate | 5 | 9% |
| Student > Master | 5 | 9% |
| Other | 7 | 12% |
| Unknown | 10 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 35% |
| Medicine and Dentistry | 8 | 14% |
| Neuroscience | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Psychology | 2 | 4% |
| Other | 6 | 11% |
| Unknown | 11 | 19% |