| Title |
Myosin Light Chain Kinase Mediates Intestinal Barrier Disruption following Burn Injury
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0034946 |
| Pubmed ID | |
| Authors |
Chuanli Chen, Pei Wang, Qin Su, Shiliang Wang, Fengjun Wang |
| Abstract |
Severe burn injury results in the loss of intestinal barrier function, however, the underlying mechanism remains unclear. Myosin light chain (MLC) phosphorylation mediated by MLC kinase (MLCK) is critical to the pathophysiological regulation of intestinal barrier function. We hypothesized that the MLCK-dependent MLC phosphorylation mediates the regulation of intestinal barrier function following burn injury, and that MLCK inhibition attenuates the burn-induced intestinal barrier disfunction. |
Mendeley readers
The data shown below were compiled from readership statistics for 49 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 49 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 22% |
| Researcher | 10 | 20% |
| Student > Master | 6 | 12% |
| Other | 4 | 8% |
| Student > Ph. D. Student | 3 | 6% |
| Other | 8 | 16% |
| Unknown | 7 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 29% |
| Agricultural and Biological Sciences | 8 | 16% |
| Biochemistry, Genetics and Molecular Biology | 5 | 10% |
| Immunology and Microbiology | 4 | 8% |
| Nursing and Health Professions | 2 | 4% |
| Other | 4 | 8% |
| Unknown | 12 | 24% |