Title |
Confocal Laser Scanning Microscopy, a New In Vivo Diagnostic Tool for Schistosomiasis
|
---|---|
Published in |
PLOS ONE, April 2012
|
DOI | 10.1371/journal.pone.0034869 |
Pubmed ID | |
Authors |
Carlos Fritzsche, Oliver Stachs, Martha Charlotte Holtfreter, Constanze Nohr-Łuczak, Rudolf Friedrich Guthoff, Emil Christian Reisinger |
Abstract |
The gold standard for the diagnosis of schistosomiasis is the detection of the parasite's characteristic eggs in urine, stool, or rectal and bladder biopsy specimens. Direct detection of eggs is difficult and not always possible in patients with low egg-shedding rates. Confocal laser scanning microscopy (CLSM) permits non-invasive cell imaging in vivo and is an established way of obtaining high-resolution images and 3-dimensional reconstructions. Recently, CLSM was shown to be a suitable method to visualize Schistosoma mansoni eggs within the mucosa of dissected mouse gut. In this case, we evaluated the suitability of CLSM to detect eggs of Schistosoma haematobium in a patient with urinary schistosomiasis and low egg-shedding rates. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 23% |
Student > Bachelor | 6 | 17% |
Other | 4 | 11% |
Student > Doctoral Student | 2 | 6% |
Lecturer | 2 | 6% |
Other | 7 | 20% |
Unknown | 6 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 11 | 31% |
Agricultural and Biological Sciences | 4 | 11% |
Immunology and Microbiology | 3 | 9% |
Biochemistry, Genetics and Molecular Biology | 2 | 6% |
Physics and Astronomy | 2 | 6% |
Other | 5 | 14% |
Unknown | 8 | 23% |