| Title |
Phase I Clinical Trial of Systemically Administered TUSC2(FUS1)-Nanoparticles Mediating Functional Gene Transfer in Humans
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0034833 |
| Pubmed ID | |
| Authors |
Charles Lu, David J. Stewart, J. Jack Lee, Lin Ji, Rajagopal Ramesh, Gitanjali Jayachandran, Maria I. Nunez, Ignacio I. Wistuba, Jeremy J. Erasmus, Marshall E. Hicks, Elizabeth A. Grimm, James M. Reuben, Veerabhadran Baladandayuthapani, Nancy S. Templeton, John D. McMannis, Jack A. Roth |
| Abstract |
Tumor suppressor gene TUSC2/FUS1 (TUSC2) is frequently inactivated early in lung cancer development. TUSC2 mediates apoptosis in cancer cells but not normal cells by upregulation of the intrinsic apoptotic pathway. No drug strategies currently exist targeting loss-of-function genetic abnormalities. We report the first in-human systemic gene therapy clinical trial of tumor suppressor gene TUSC2. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Japan | 1 | <1% |
| India | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 122 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 27% |
| Researcher | 21 | 17% |
| Student > Master | 11 | 9% |
| Student > Bachelor | 11 | 9% |
| Professor > Associate Professor | 7 | 6% |
| Other | 18 | 14% |
| Unknown | 25 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 21 | 17% |
| Biochemistry, Genetics and Molecular Biology | 20 | 16% |
| Medicine and Dentistry | 14 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 11% |
| Chemistry | 5 | 4% |
| Other | 20 | 16% |
| Unknown | 33 | 26% |