| Title |
Haplotype Analyses of Haemoglobin C and Haemoglobin S and the Dynamics of the Evolutionary Response to Malaria in Kassena-Nankana District of Ghana
|
|---|---|
| Published in |
PLOS ONE, April 2012
|
| DOI | 10.1371/journal.pone.0034565 |
| Pubmed ID | |
| Authors |
Anita Ghansah, Kirk A. Rockett, Taane G. Clark, Michael D. Wilson, Kwadwo A. Koram, Abraham R. Oduro, Lucas Amenga-Etego, Thomas Anyorigiya, Abraham Hodgson, Paul Milligan, William O. Rogers, Dominic P. Kwiatkowski |
| Abstract |
Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolutionary history of the malaria-protective alleles HbS and HbC in the Kassena-Nankana District (KND) of Ghana. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 4% |
| Burkina Faso | 1 | 2% |
| Ghana | 1 | 2% |
| Indonesia | 1 | 2% |
| Kenya | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 45 | 87% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 37% |
| Researcher | 10 | 19% |
| Professor | 4 | 8% |
| Student > Master | 3 | 6% |
| Student > Bachelor | 2 | 4% |
| Other | 5 | 10% |
| Unknown | 9 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 31% |
| Biochemistry, Genetics and Molecular Biology | 9 | 17% |
| Medicine and Dentistry | 7 | 13% |
| Mathematics | 4 | 8% |
| Social Sciences | 3 | 6% |
| Other | 3 | 6% |
| Unknown | 10 | 19% |