Report for: Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei

Title	Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei
Published in	PLOS ONE, April 2012
DOI	10.1371/journal.pone.0034530
Pubmed ID	22506025
Authors	Melisa Gualdron-López, Miia H. Vapola, Ilkka J. Miinalainen, J. Kalervo Hiltunen, Paul A. M. Michels, Vasily D. Antonenkov
Abstract	Glycosomes are a specialized form of peroxisomes (microbodies) present in unicellular eukaryotes that belong to the Kinetoplastea order, such as Trypanosoma and Leishmania species, parasitic protists causing severe diseases of livestock and humans in subtropical and tropical countries. The organelles harbour most enzymes of the glycolytic pathway that is responsible for substrate-level ATP production in the cell. Glycolysis is essential for bloodstream-form Trypanosoma brucei and enzymes comprising this pathway have been validated as drug targets. Glycosomes are surrounded by a single membrane. How glycolytic metabolites are transported across the glycosomal membrane is unclear.

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Members of the public	3	100%

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Readers by professional status	Count	As %
Student > Ph. D. Student	17	28%
Researcher	16	26%
Student > Master	6	10%
Student > Bachelor	5	8%
Professor	1	2%
Other	3	5%
Unknown	13	21%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	23	38%
Biochemistry, Genetics and Molecular Biology	18	30%
Chemistry	5	8%
Psychology	1	2%
Arts and Humanities	1	2%
Other	0	0%
Unknown	13	21%

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