| Title |
IFITM Proteins Restrict Antibody-Dependent Enhancement of Dengue Virus Infection
|
|---|---|
| Published in |
PLOS ONE, March 2012
|
| DOI | 10.1371/journal.pone.0034508 |
| Pubmed ID | |
| Authors |
Ying Kai Chan, I-Chueh Huang, Michael Farzan |
| Abstract |
Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 83 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| French Polynesia | 1 | 1% |
| Netherlands | 1 | 1% |
| Saint Kitts and Nevis | 1 | 1% |
| Indonesia | 1 | 1% |
| Brazil | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 77 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 29% |
| Researcher | 15 | 18% |
| Student > Master | 13 | 16% |
| Student > Bachelor | 8 | 10% |
| Student > Doctoral Student | 6 | 7% |
| Other | 11 | 13% |
| Unknown | 6 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 39 | 47% |
| Immunology and Microbiology | 12 | 14% |
| Medicine and Dentistry | 11 | 13% |
| Biochemistry, Genetics and Molecular Biology | 10 | 12% |
| Social Sciences | 2 | 2% |
| Other | 2 | 2% |
| Unknown | 7 | 8% |