| Title |
Multi-Level Communication of Human Retinal Pigment Epithelial Cells via Tunneling Nanotubes
|
|---|---|
| Published in |
PLOS ONE, March 2012
|
| DOI | 10.1371/journal.pone.0033195 |
| Pubmed ID | |
| Authors |
Dierk Wittig, Xiang Wang, Cindy Walter, Hans-Hermann Gerdes, Richard H. W. Funk, Cora Roehlecke |
| Abstract |
Tunneling nanotubes (TNTs) may offer a very specific and effective way of intercellular communication. Here we investigated TNTs in the human retinal pigment epithelial (RPE) cell line ARPE-19. Morphology of TNTs was examined by immunostaining and scanning electron microscopy. To determine the function of TNTs between cells, we studied the TNT-dependent intercellular communication at different levels including electrical and calcium signalling, small molecular diffusion as well as mitochondrial re-localization. Further, intercellular organelles transfer was assayed by FACS analysis. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 97 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Italy | 1 | 1% |
| Austria | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 93 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 32 | 33% |
| Researcher | 13 | 13% |
| Student > Master | 11 | 11% |
| Student > Bachelor | 8 | 8% |
| Student > Doctoral Student | 4 | 4% |
| Other | 14 | 14% |
| Unknown | 15 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 28 | 29% |
| Biochemistry, Genetics and Molecular Biology | 21 | 22% |
| Medicine and Dentistry | 12 | 12% |
| Chemistry | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 13 | 13% |
| Unknown | 16 | 16% |