| Title |
Leptin Resistance in Vagal Afferent Neurons Inhibits Cholecystokinin Signaling and Satiation in Diet Induced Obese Rats
|
|---|---|
| Published in |
PLOS ONE, March 2012
|
| DOI | 10.1371/journal.pone.0032967 |
| Pubmed ID | |
| Authors |
Guillaume de Lartigue, Claire Barbier de la Serre, Elvis Espero, Jennifer Lee, Helen E. Raybould |
| Abstract |
The gastrointestinal hormone cholecystokinin (CCK) plays an important role in regulating meal size and duration by activating CCK1 receptors on vagal afferent neurons (VAN). Leptin enhances CCK signaling in VAN via an early growth response 1 (EGR1) dependent pathway thereby increasing their sensitivity to CCK. In response to a chronic ingestion of a high fat diet, VAN develop leptin resistance and the satiating effects of CCK are reduced. We tested the hypothesis that leptin resistance in VAN is responsible for reducing CCK signaling and satiation. |
Mendeley readers
The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 1 | 1% |
| Unknown | 96 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 17% |
| Student > Bachelor | 15 | 15% |
| Researcher | 12 | 12% |
| Student > Master | 12 | 12% |
| Student > Doctoral Student | 9 | 9% |
| Other | 18 | 18% |
| Unknown | 16 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 22% |
| Agricultural and Biological Sciences | 19 | 19% |
| Biochemistry, Genetics and Molecular Biology | 9 | 9% |
| Neuroscience | 8 | 8% |
| Immunology and Microbiology | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 20 | 20% |