| Title |
Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis
|
|---|---|
| Published in |
PLOS ONE, February 2012
|
| DOI | 10.1371/journal.pone.0032479 |
| Pubmed ID | |
| Authors |
Aditya K. Padhi, Hirdesh Kumar, Suhas V. Vasaikar, Bhyravabhotla Jayaram, James Gomes |
| Abstract |
Mutations in the coding region of angiogenin (ANG) gene have been found in patients suffering from Amyotrophic Lateral Sclerosis (ALS). Neurodegeneration results from the loss of angiogenic ability of ANG (protein coded by ANG). In this work, we performed extensive molecular dynamics (MD) simulations of wild-type ANG and disease associated ANG variants to elucidate the mechanism behind the loss of ribonucleolytic activity and nuclear translocation activity, functions needed for angiogenesis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 2 | 3% |
| Korea, Republic of | 1 | 2% |
| India | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 59 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 15 | 23% |
| Student > Bachelor | 11 | 17% |
| Student > Master | 8 | 13% |
| Student > Doctoral Student | 6 | 9% |
| Researcher | 6 | 9% |
| Other | 12 | 19% |
| Unknown | 6 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 20 | 31% |
| Biochemistry, Genetics and Molecular Biology | 11 | 17% |
| Medicine and Dentistry | 9 | 14% |
| Neuroscience | 5 | 8% |
| Chemistry | 4 | 6% |
| Other | 8 | 13% |
| Unknown | 7 | 11% |